Fault tree construction for hazard assessment requires so much time and labor, so it is very difficult to be applied to the large scale chemical plant. In this study, for the synthesis of fault tree in chemical processes, the object-oriented knowledge framework is proposed to represent the deviations of process variables in the equipment and cause-consequence relationship with equipment faults. The cause of fault is searched by using the object-oriented modeling of equipments and the connectivity among equipments, and then a fault tree is synthesized. we have discussed the performance of the methodology on nitric acid cooling process to evaluate its effectiveness.