The leaves and flowers of Hemisteptia lyrata Bunge (Compositae) have been used for cure sour throat and treat tumors in traditional chinese medicine. As a result of the chemical investigation, two compounds were isolated from the $CHCl_3$ extract of the flowers of H. lyrata. On the basis of spectroscopic experiments, their structures were identified as 8-hydroxy-3-keto-10(14)-guaien-12,6-oxide (Isoamberboin) and 3,8-dihydroxy-4(15),10(14),11(13)-guaiatrien-12,6-oxide (8-Hydroxyzaluzanin C). They were first isolated from the genus Hemisteptia.