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가토에서 $TGF-{eta}$ 길항제인 Decorin이 창상치유에 미치는 영향
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  • 가토에서 $TGF-{eta}$ 길항제인 Decorin이 창상치유에 미치는 영향
저자명
송상훈,유준영,김선헌,김민석,양병은,Song. Sang-Hun,You. Jun-Young,Kim. Sun-Hun,Kim. Min-Suk,Yang. Byung-Eun
간행물명
大韓口腔顎顔面外科學會誌
권/호정보
2001년|27권 4호|pp.301-307 (7 pages)
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대한구강악안면외과학회
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

There have been many trials to decrease the scar formation followed by wound treatment. $TGF-{eta}$ plays a important role on wound healing in adult. Therefore the repression of $TGF-{eta}$ expression will be helpful to decrease scar formation. Decorin is known to competitively inhibit $TGF-{eta}$ expression. Decorin were subcutaneously administered in surgical wounds in rabbits to investigate the preventing effect of scar formation for clinical application. Histologic findings of wound healing progresses is similar with control and experimental group at 2week. $2.5{mu}g$ decorin of administrated group was similar to those of control group at 4 and 8week. In wound healing process $10{mu}g$ decorin of administrated groupsat showed that thickness of immature collagen fibers(scar) was decreased as compared with control group at 4, 8 weeks. $20{mu}g$ decorin of administrated group showed similar histologic features to $10{mu}g$ administrated group. The wounds of 8week experimental group(10, $20{mu}g$) were completely recovered to the normal surrounding skin tissue including sweat gland and hair follicle. These results suggested that decorin can be of help to the prevention of local scar formation.