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보중익기탕(補中益氣湯), 소음인(少陰人) 보중익기탕(補中益氣湯)과 그 구성약물군(構成藥物群)이 alloxan으로 유발(誘發)된 고혈당(高血糖) 백서(白鼠)에 미치는 영향(影響)
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  • 보중익기탕(補中益氣湯), 소음인(少陰人) 보중익기탕(補中益氣湯)과 그 구성약물군(構成藥物群)이 alloxan으로 유발(誘發)된 고혈당(高血糖) 백서(白鼠)에 미치는 영향(影響)
저자명
박선동,고원도,신화석,Park. Seon-Dong,Go. Won-Do,Sin. Hwa-Seok
간행물명
大韓韓醫學方劑學會誌
권/호정보
2001년|9권 1호|pp.215-230 (16 pages)
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대한한의학방제학회
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

The purpose of this study was to investigate the effect of Bojungikgitang(補中益氣湯), Soeumin bojungikgitang(少陰人 補中益氣湯) and its component groups on diabetes in alloxan induced diabetic rats. Sprague-Dawley male rats weighing $200{pm}10;gm$ were randomly assigned to one normal, one control and five experimental groups. The experimental groups was classified into to Bojungikgitang(B1 group), Soeumin bojungikgitang(B2 group), Bogihyulyak(B0 group), Siho-sengma(B1+ group) and Gwakhyang- soyeup(B2+ group). Diabetes was experimentally induced by abdomenal injection of 100 mg/kg of body weight of alloxan. Animals were sacrificed at the 6th day and 11th day of diabetic states. The results were obtained as follows: In carbohydrate metabolism, the level of glucose in control group was three-fold higher after alloxan injection than that of normal group. In B1, B2 groups the level of glucose was decreased by 39% and 43% compared with that of control group, and in component groups it was decreased by 73%, 81%, and 80% respectively. In fat metabolism, the level of triglyceride and total cholesterol in serum were lower in B1 and B2 groups with high significant difference and had similar tendency in components groups compared with that of control group. The level of HDL cholesterol on serum were increased in B1 and B2 group with significant difference. And in component group it had similar tendency compared with that of control group. In protein metabolism, the level of total protein and albumin were higher in B1 and B2 group with significant difference, and in component group also increased but with no significancy compared with control group. In kidney function, the level of creatinine group with significant difference, and other compared with control group. In liver function, the level of GOT, GPT, ${gamma}$-GTP. ALP and bilirubin were lower in B1 and B2 group with significant difference, and in component had similar tendency compared with control group. But in the level of LDH, it was decreased with no significancy. These results indicate that Bojungikgitang(補中益氣湯), Soeumin bojungikgitang(少陰人 補中益氣湯) has strong effect on diabetes and it is useful to prevent diabetes, and in component groups the difference between B1+ and B2+ group was not significant.