The very large floating structure which can be used for as airport may be as large as several kilometer long and wide. The first order wave forces as well as wave drift forces are very important forces on such a very large floating structures. In the present study, the time simulation of motion responses for dolphin-moored VLFS in waves is presented. The hydrodynamic coefficients and wave forces involved in the equations are obtained from a three-dimensional panel method in the frequency domain. The horizontal drift forces and mooring forces for dolphin systems are taken into account. As for numerical example, time domain analyses are carried out for a VLFS(Phase I) in irregular wave condition.