The purpose of this study was to investigate the effects of family stress on work stress and to examine the effects of family and work stress on psychological wellbeing in employed men and women. The analyses of the present study were based on a sample of 263 full-time employed men and 258 full-time employed women aged 30-49 in dual-earner families. There were significant gender differences in marital stress, parenting stress and psychological well-being with women reporting higher levels of stress. However, employed men and women experienced similar levels of work stress. The results from regression analyses showed that stress in the family domain contributed significantly to work stress. Both marital stress and parenting stress were significantly related to higher levels of work stress fro employed men and women. The findings of this study indicated that higher levels of marital stress and work stress were predictive of psychological well-being for men and women in dual-earner couples. Among employed women, marital stress and work stress were more highly related to psychological well-being than among employed men.