This paper represents the numerical analysis for microenvironments various temperature and humidity in bed mattress. He purpose of this study is for healthful bed mattress by controling a bacteria with a prediction of the vapor and temperature distributions in the bed mattress. The numerical model is one dimensional unsteady state and the governing equations were discretized by fully implicit scheme. The numerical results were compared with experimental data, and showed a good agreement with them. Specially, the excess-relative humidity shows a lower distribution near the surface of mattress, meaning that the optimum living condition for bacteria will be caused.