This paper presents leakage characteristics of a scroll compressor applying alternative refrigerants of R22 such as R407c and R410a under actual operating conditions. Because leakage in a scroll compressor produce significant losses and degradation of performance, those should be clarified to design a high efficient scroll compressor with alternative refrigerants of R22. However, flank and tip leakage characteristics of a scroll compressor with alternative refrigerants are very limited in open literature. In the present study, both experimentation and modeling of the leakages in the scroll compressor were performed. As a result, it was observed that the leakages of the scroll compressor with R407c increased by 15%, and that with R410a increased by 76% as compared to the compressor applying R22 under standard load conditions due to a higher upstream pressure and a higher pressure difference between pockets.