Experiments on the condensation heat transfer characteristics inside a smooth and a microfin tube with R410A/R22 are performed in this study. The test tubes 7/9.52 mm in outside diameters and 3m in length are used. Varying the mass flux of the refrigerant and the condensation temperatures, the average heat transfer coefficients and pressure drop are investigated. Most flows in this study are in the annular and/or wavy flow regime. It is shown that the heat transfer is enhanced and the pressure drops are larger in the microfin tube than the smooth tube. From the heat transfer enhancement coefficients and the pressure drops, it is found that the high heat transfer enhancement factors are obtained in the range of small mass flux while the penalty factors are almost equal. Experiments results show that average heat transfer coefficients of R410A is larger than that of R22 and pressure drop of R410A is less than R22.