High-speed and low-speed flows are simulated numerically by flowfield-dependent mixed explicit-implicit (FDMEI) method. This algorithm depends on implicitness parameters of convection, diffusion, diffusion gradients, and source terms which are calculated from the changes of local Mach, Reynolds, Peclet, and Damkohler numbers between adjacent nodes. Convection phenomena or shock waves are resolved from Mach number-dependent implicitness parameters whereas diffusion or viscous actions are simulated by Reynolds number or Peclet number-dependent implicitness parameters. Fluctuation components of all variables are properly accommodated spatially and temporally in the FDMEI procedure. To illustrate, some benchmark example problems are presented for comparisons of the FDMEI results with other available data. These results appear to be encouraging and point toward the need for further investigations of the FDMEI theory.