We investigate mechanical anisotropy dependent of rock fabric and its relationship with microcracks in the Pocheon Granite. Uniaxial compressive strengths range from 177MPa to 212MPa and the elastic constants are 48GPa-62GPa. The tensile strengths are 6.9MPa~8.5MPa and ultrasonic wave velocities range between 3,200m/sec and 3,700m/sec, indicating that mechanical anisotropy is strongly dependent of rock fabric. The minimum anisotropy ratio is 14% and the maximum is 24%, depend on the mechanical properties. The preferred orientations of microcracks are closely related with the directions of rock fabric. The preferred orientations of microcracks in feldspar are governed by the direction of mineralogical axis and are different from the directions of rock fabric. However, microcracks in quartz grains are very long and parallel to the directions of rock fabric, indicating that directions of rock fabric may be governed by the preferred orientations of microcracks in quartz grains. The preferred orientations of microcracks measured by differential strain analysis and microscopic observation are slightly different. That may be caused by different methodology. Lengths and numbers of microcrack are measured by microscopic observation. However, differential strain analysis measures the widths of microcracks.