Recently there were many studies not only to enhance drug delevery effect but to reduce side effect. Drug delivery system efficiency with decreasing side effect of drug dosage. It made possibility to use for a long term. Polymer drug was prepared by acid halide method with polymer in such of polyacylic acid and sulfacetamide. Its chemical properties were identified by means of IR, TGA. The antibacterial activities of polymer drug were studied by MICs and disk susceptivility test. The antibacterial activities by clean zone were increased in order of Staphyloccus aures <Escherichia Coli.<Streptococcus pyrogenes<Pseudomonas aeruginosa at disk susceptibility test. The antibacterial activities of polymer drug against variety bacillus were excellent compared to those of control drug such as sulfacetamide.