The water quality simulation was carried out to predict water quality in Tan stream of the Han river using water quality model, QUAL2E. In the end, the future variations in water quality of Tan stream were simulated and the prediction of the impacts of Tan stream on water quality in the Han river was carried out by applying the Tan stream simulation results into the model. The results are as follows. The predicted results of future water quality of Tan stream suggested that the concentrations of BOD, T-N and T-P at Chungdam bridge would increase to 0.68~0.77 mg/$ell$, 1.33~1.62 mg/$ell$ and 0.05~0.06 mg/$ell$, respectively in 2006 and 2011 and that with the implementation of advanced treatment in Sungnam and Tanchun sewage treatment plants, the concentration of T-N would be reduced more as the amount of treated sewage increase, while the concentration of T-P would stay 0.49 mg/$ell$. The results obtained from simulation of the impacts of future Tan stream water quality improvement on the main stream of the Han river showed that with implementation of advanced treatment in both Sungnam and Tanchun sewage treatment plants, the concentration of T-N, T-P and chlorophyll-a at Hangang bridge and Heangju bridge would be reduced by 11.6%, 7.7% and 20.9%, respectively in 2..6 and by 13.6%, 9.4% and 22.2%, respectively in 2011, which indicates that the effect on the reduction of T-N and T-P would be relatively significant while the effect on the decrease of algae would be slight.