The present study revealed that polyphenol induces the hibernation of mammalian cells at the living body temperature. It was found that polyphenol is a cytostatic sleeping agent for mam-malian cells, where almost all cells resume proliferation after the hibernation period and cell death seldom occurs. By changing the concentration for polyphenol, various mammalian cells can be stored under different conditions, such as temporary sleep, and hibernation condi-tions.