In this study, we developed a FFPI (fiber optic Fabry-Perot interferometer) pressure sensor using the Si diaphragm which measures pressure in vivo. The diaphragm and its supporting structure were etched in KOH solution and were fabricated with micromachining technology. For the configuration of the sensor, the length of the cavity of the Fabry-Perot etalon is 15 mm and one end of the etalon was bonded to a Si diaphragm with 507m thickness. When the area of the Si diaphragm was 2$ imes$2 mm2 (cavity length 15 mm), it turns out that the pressure sensitivity was about 1.5 degree/kPa. The pressure sensor developed in this study showed that the phase change was linearly proportional to the increasing pressure in the range of 80 kPa.