This paper presents the simulation methodology of the interior noise of vehicle using the frequency response function based hybrid modeling of the system which consists of multi-subsystem models obtained by the test or analysis. The complex systems such as a trimmed body of high modal density and a powertrain were modeled by using experimental data, and a sub-frame of a vehicle of low modal density was modeled by finite element data. Modeling of the whole system was executed and validated in the two stages. The first stave is combining the trimmed body and the sub-frame, and the second stage is attaching the powertrain, which is a exciting source, to the combined model of the first stage. The input force to the system was modeled as an equivalent force in the virtual space, which was obtained from impedance method using the FRFs of the powertrain and the responses. The interior noise predicted by the proposed method was very close to the direct measurement, which showed feasibility of the proposed modeling procedure. Since the methodology is easily applied to both the transfer path analysis of structure-borne noise and the analysis of noise contribution of a sub-system, it is expected to be a strong tool for design change of a vehicle in the earlier stare.