This paper intends to set up a standard sets of indicators based on system-orientor framework, in assuming urban place as a self-organizing system within which several subsystems are interlinked together. Also, The application guideline composed of normative-analytical-practical dimensions, is proposed how to put into practice a standard set of indicators according to the regional characteristics. In practice, Seongnam in Gyeonggi Province in Korea and St. Paul in Minnesota in US are selected for case studies in order to measure and evaluate urban sustainability. Both data availability for measured variables and establishment of minimum level and satisfactory level of sustainability are requested for furthermore researches.