It is known that the elastic modulus, maximum stress, and maximum strain of fiber-reinforced polymer composites are affected by high pressure. Fracture behavior is also known to be affected by high pressure. In this work, the pressure effect on the compressive fracture toughness of thick quasi-isotropic composites was investigated. Dog-bone type specimens of stacking sequence, [0$^{circ}$/$pm$45$^{circ}$/90$^{circ}$]$_{11s}$ were used. Compressive fracture tests were conducted under four pressure levels. The pressure levels applied were 0.1 MPa, 100 MPa, 200 MPa, and 300 MPa. Fracture toughness for each pressure level was determined from the compliance method. The results show that the compressive fracture toughness increases with increasing pressure. Specifically, fracture toughness increases 44% as the pressure increases from 0.1 MPa to 300 MPa.