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Identification and Phylogeny of the Human Endogenous Retrovirus HERV-W LTR Family in Schizophrenia
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  • Identification and Phylogeny of the Human Endogenous Retrovirus HERV-W LTR Family in Schizophrenia
  • Identification and Phylogeny of the Human Endogenous Retrovirus HERV-W LTR Family in Schizophrenia
저자명
Huh. Jae-Won,Yi. Joo-Mi,Kim. Heui-Soo
간행물명
Journal of life science
권/호정보
2001년|11권 2호|pp.83-86 (4 pages)
발행정보
한국생명과학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

The long terminal repeat (LTR) elements of human endogenous retrovirus (HERV) have been found to be coexpressed with genes located nearby. It has been suggested that the LTR elements have contributed to the genetic variation of human genome connected to various diseases. Recently, HERV-W family was identified in the cerebrospinal fluids and brains of individuals with schizophrenia. Using genomic DNAs derived from schizophrenia, we performed PCR amplification and identified six HERV-W LTR elements. Those LTR elements showed a high degree of sequence similarity (87.7-99.5%) with HERV-W LTR (AF072500). Sequence analysis of the HERV-W LTR elements revealed that clone W-sch1 showed identical sequence with the AC003014 (PAC clone RP1-290B4) derived from human Xq23. Clone W-sch2 was closely related to the AC0072442 derived from human Y chromosome by phylogenetic analysis. Our data suggest that new HERV-W LTR elements in schizophrenia may be very useful for further studies to understand neuropsychiatric diseases.