This paper presents a loop-based genetic algorithm for loss minimization of distribution systems by automatic sectionalizing switch operation in distribution systems. Genetic algorithm can be successfully applied to problem of loss minimization in distribution systems because it is suitable to solve combinatorial optimization problems. New loop-based string structure is proposed for generating the more feasible solutions, and the proposed restoration function converts infeasible solutions into feasible solutions. The loop-based genetic algorithm with sam adaptations have been applied to improve the computation time and convergence property. Numerical examples demonstrate the validity and effectiveness of the proposed methodology using a 32-bus and 69-bus system.