Purpose: Radiofrequency ablation (RFA) of lung cancer in animals and humans has been described in previously published reports. The aim of this study was to present our preliminary experience of treatment of lung cancer involving this approach. Materials and Methods: Eight patients with lung malignancies rstage IIIB or IV bronchogenic adenocarcinoma (n= 6), metastatic squamous cell carcinoma (n = 1), metastatic hepatocellular carcinoma (n = 1)] underwent RFA treatment. In all cases LeVeen-type electrodes were employed and CT was used to monitor the procedure. One-day and one-month follow-up CT scans were obtained and analyzed. Results: Prior to treatment, tumor diameter ranged from 2.5 to 5 cm; afterwards, low attenuation consistent with coagulative necrosis was observed. Complications included a small amount of pneumothorax (n = 4), pleural effusion (n = 8), and subcutaneous emphysema (n = 1). Tumor size decreased in five patients, was unchanged in two, and increased in one. Conclusion: Radiofrequency ablation of lung cancer is safe and may result in a reduced tumor burden.