Squamous cell carcinoma was diagnosed in a 4.5-year-old male African hedgehog (Atelerix albiventris). The patient was referred to Seoul National University, Veterinary Medical Teaching Hospital after 5 days history of left eye exophthalmos and corneal trauma. He had enlarged upper and lower jaw at the left part of the face and endophthalmitis of the left eye. On radiographic examinations, loss of bone density at the left zygomatic arch and sun-burst type periosteal reaction of left mandible with decreased bone density was noted. Histologically, the neoplastic mass consisted of markedly invasive, cords of nests of squamous epithelial cells. Intercellular bridges and keratin pearl formation were also noted.