Chiral Separation of ${eta}_2$-Agonists by Capillary Electrophoresis Using Hydroxypropyl-${alpha}$-Cyclodextrin as a Chiral Selector

Chiral Separation of ${eta}_2$-Agonists by Capillary Electrophoresis Using Hydroxypropyl-${alpha}$-Cyclodextrin as a Chiral Selector
Chiral Separation of ${eta}_2$-Agonists by Capillary Electrophoresis Using Hydroxypropyl-${alpha}$-Cyclodextrin as a Chiral Selector

ㆍ 저자명: Kim. Kyeon-Ho,Kim. Hyu-Ju,Jeun. Eu-Young,Seo. San-Hun,Hong. Seon-Pyo,Kang. Jong-Seong,Youm. Jeong-Rok,Lee. Sang-Cheal
ㆍ 간행물명: Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
ㆍ 권/호정보: 2001년|24권 4호|pp.281-285 (5 pages)
ㆍ 발행정보: 대한약학회
ㆍ 파일정보: 정기간행물|ENG|
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ㆍ 주제분야: 기타

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기타언어초록

Enantiomers of five racemic ${eta}_2$-agonists were investigated by capillary electrophoresis employing a hydroxypropyl-${eta}$-cyclodextrin (HP-${eta}$-CD). The effects of the concentration of HP-${eta}$-CD added to the background electrolyte and of the pH of the buffer on the effective mobility and resolution of the studied compounds were examined. Very good resolution was achieved for terbutaline and clenbuterol; salbutamol and bambuterol was able to be partially resolved. Enantioselectivity and resolution were influenced by the concentration of the HP-7-CD, buffer composition and pH.

키워드

Capillary electrophoresis Chiral separation Hydroxypropyl-${eta}$-cyclodextrin ${eta}_2$-agonists

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