Nob1e2-[3-(Cyclopentyloxy)-4-Methoxyphenyl]-1-Isoindolinone Derivatives. PartI: Synthesis and SAR Studies for the Inhibition of TNF-$alpha$ Production

Nob1e2-[3-(Cyclopentyloxy)-4-Methoxyphenyl]-1-Isoindolinone Derivatives. PartI: Synthesis and SAR Studies for the Inhibition of TNF-$alpha$ Production
Nob1e2-[3-(Cyclopentyloxy)-4-Methoxyphenyl]-1-Isoindolinone Derivatives. PartI: Synthesis and SAR Studies for the Inhibition of TNF-$alpha$ Production

ㆍ 저자명: Park. Joon-Seok,Baik. Kyong-Up,Cho. Jae-Youl,Yoo. Eun-Sook,Byun. Young-Seok,Park. Myung-Hwan
ㆍ 간행물명: Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
ㆍ 권/호정보: 2001년|24권 5호|pp.367-370 (4 pages)
ㆍ 발행정보: 대한약학회
ㆍ 파일정보: 정기간행물|ENG|
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ㆍ 주제분야: 기타

이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.

서지반출

기타언어초록

This study describes the synthesis and in vitro evaluation of noble 2-[3-(cyclopentyloxy)-4-methoxyphenyl]-1-isoindolinone Derivatives for the inhibition of TNF-$alpa$ production. Among these compounds, 2- [3- (Cyclopentyloxy)- 4- methoxyphenyll- 3- methyl -1 - isoindolinone (5) was the most potent in inhibitory activity of TNF-$alpa$ production in LPS-stimulated RAW264.7 cells.

키워드

2-[3-(Cyclopentyloxy)-4-methoxyphenyl]-1-isoindolinone TNF-$alpha$ inhibitor Structure-activity relationship RAW264 7 cells

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