In logistics decision making, Key elements in the design of any physical distribution are the location of depots and the distribution of goods from the depots to the customers. Considering open and close the depots, This paper presents a flexible analysis on the combined location-routing problem(LRP) the case for variation capacity of vehicle and customers demands each. The scenario examples are given the use of heuristic(Saving-Drop) in LRP types. The results is useful in apply to the logistics environment changes.