With increasing globalization, a proper policy for global inter-city networking strongly required, which presumes the study on the heterogeneity among regional innovation systems. While surveying the research results of the Evolutionary Economics, 1 stress that regional systems of innovation differ in technological capacities, industrial structures, institutional arrangements and socio-cultural features. 1 make the empirical investigation based on the data of Busan and Hamburg, making clear the regional specificities among regional innovation systems. The results show that regional systems of innovation in Busan and Hamburg are quitely asymmetric. They suggest also the limitation of neo-classical assumption on the ‘homogeneous production function’ and that policy-makers in regions should make the policy for ‘global inter-cities networking’, based on perspectives of regional heterogeneity.