본 실험은 한국재래산양에 있어서 분만 후 초기에 prostaglandin $F_{2{alpha}}$(PG $F_{2{alpha}$)의 투여가 호르몬 농도 및 난포발육에 미치는 효과를 검토하기 위하여 수행되었던 바 그 결과는 다음과 같다. 1. 분만한 한국재래산양에 혈장중 PG $F_{2{alpha}}$의 농도는 PG $F_{2{alpha}}$처리 후 2일에 PG $F_{2{alpha}}$처리군 (GR-1 및 GR-2)에서 각각 6.35$pm$0.5 및 0.22$pm$0.2pg/$mell$로서 저하한 후 점차 증가하여 4일 후 21.18$pm$1.6 및 4.21$pm$0.4 pg/$mell$로서 절정에 도달하였다. 2. 혈장중 PG $F_{2{alpha}}$의 농도는 PG $F_{2{alpha}}$ 처리 전 9.08$pm$1.2 및 5.44$pm$1.8 pg/$mell$였으며 처리후 농도는 다소 저하하였으나 처리 군간에 유의차는 없었다. 3. 혈장중 estradiol-l7$eta$( $E_2$)농도는 PG $F_{2{alpha}}$ 처리 후 2일까지 점차 감소한 후 3일에 증가하여 4일에 최대치에 도달하였다. 4. 혈장중 luteinizing hormone (나T)의 농도는 PG $F_{2{alpha}}$ 처리 후 약간의 증가가 있었으나 유의한 차이는 없었다. 5. 혈장중 prolactin (PRL)의 농도는 PG $F_{2{alpha}}$처리후 감소되었으나 저농도의 수준으로 남아 있었다. 6. PG $F_{2{alpha}}$의 처리 후 소형 및 중형의 난포의 수는 거의 유사하였으나 4mm 이상 대형 난포의 수는 숫적로 증가하는 경향을 보였다. 이상의 결과로 보아 PG $F_{2{alpha}}$ 및 estradiol-17$eta$는 난포의 직경과 관계가 있다고 암시되며 PG $F_{2{alpha}}$는 난포발육을 촉진하였다고 생각된다.
These experiments were conducted to evaluate the effects of the administration of exogenous PG $F_{2{alpha}}$ on hormone concentrations and follicular development in early postpartum(pp) Korean native goats. 1. Plasma PG $F_{2{alpha}}$ concentrations in PG $F_{2{alpha}}$ treated goals showed a gradual increase from a low on day 2 (GR-1 : 10 day-treatment group: 6.35$pm$0.5 and GR-2; 4 day-treatment group: 0.22$pm$0.2 pg/$mell$, respectively) to reach a peak of 21.18$pm$1.6 or 4.21 $pm$0.4 pg/$mell$ on day 4 after treatment of PG $F_{2{alpha}}$. 2. Plasma PG $F_{2{alpha}}$ concentrations in GR-1 goats averaged 9.08 $pm$1.2 pg/$mell$ compared with 5.44$pm$ 1.8 pg/$mell$ in GR-2 goats the day before treatment of PG $F_{2{alpha}}$. Mean PG $F_{2{alpha}}$ concentrations thereafter remained low during the treatment period but PG $F_{2{alpha}}$ concentrations did not differ between the two group. 3. Plasma concentrations of estradiol-17 $eta$ (E,) in PG $F_{2{alpha}}$ - treated group were decreased gradually until 2 days after PG $F_{2{alpha}}$ treatment but mean $E_2$ concentrations began to increase on 3 days and were Inaximal on the 4 days after treatment. 4. Plasma lulenizing hormone (LH) concentrations in PG $F_{2{alpha}}$ - treated goats were slightly higher than in controls but mean LH concentrations did not differ between the two treatment groups. 5. Plasma prolactin (PRL) concentrations were suppressed in both GR-1(10 day-treatment group) and GR-2(4 day-treatment group) goats compared to saline controls but mean PRL concentrations remained lower in PG $F_{2{alpha}}$ treated animals during post-treatment period. 6. The mean number of small and medium follicles present when PG $F_{2{alpha}}$ was administrated was similar in all does but the increase in number of large follicles($geq$4mm) tended to be higher in PG $F_{2{alpha}}$ treated group than controls. These results suggest that concentrations of PG $F_{2{alpha}}$ and estradiol-17$eta$ were positively correlared with follicular diameter. We conclude that PG $F_{2{alpha}}$ treatment stimulates follicular development similarly in both GR-1 and GR-2 group.
