A reliability approach to evaluate structural performance has gained increased acceptability and usage over the past two decades. Most reliability analyses are based on the reliability of an individual component without examining the entire structural system. These analyses often result in either unnecessary repairs or unsafe structures. This study uses examples of series, parallel, and series-parallel models of structural systems to illustrate how the component reliabilities affect the reliability of the entire system. The component-system reliability interaction can be used to develop optimum lifetime inspection and repair strategies for structural systems. These examples demonstrate that such strategies must be based on the reliability of the entire structural system. They also demonstrate that the location of an individual component in the system has a profound effect on the acceptable reliability of that component. Furthermore, when a structure is deteriorating over time, the reliability importance of various components is a1so changing with time. For this reason, the most critical component in the early life of the structure may not tie the most critical later.