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혈중 납과 혈압의 연관성에 관한 메타분석
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저자명
고상백,남정모,최홍열,차봉석,박종구,지호성,김춘배,Koh. Sang-Baek,Nam. Chung-Mo,Choi. Hong-Ryul,Cha. Bong-Suk,Park. Jong-Ku,Jee. Ho-Sung,Kim. Chun-Bae
간행물명
예방의학회지
권/호정보
2001년|34권 3호|pp.262-268 (7 pages)
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

Objectives : To integrate the results of studies which assess an association between blood lead and blood pressure. Methods : We surveyed the existing literature using a MEDLINE search with blood lead and blood pressure as key words, including reports published from January 1980 to December 2000. The criteria for quality evaluation were as follows: 1) the study subjects must have been workers exposed to lead, and 2) both blood pressure and blood lead must have been measured and presented with sufficient details so as to estimate or calculate the size of the association as a continuous variable. Among the 129 articles retrieved, 13 studies were selected for quantitative meta-analysis. Before the integration of each regression coefficient for the association between blood pressure and blood lead, a homogeneity test was conducted. Results : As the homogeneity of studies was rejected in a fixed effect model, we used the results in a random effect model. Our quantitative meta-analysis yielded weighted regression coefficients of blood lead associated with systolic blood pressure and diastolic blood pressure results of 0.0047 (95% confidence interval [CI]: -0.0061, 0.0155) and 0.0004 (95% CI: -0.0031, 0.0039), respectively. Conclusions : The published evidence suggested that there may be a weak positive association between blood lead and blood pressure, but the association is not significant.