The paper discusses the problem of finding the Origin-Destination(O-D) shortest paths in internodal transportation networks with time-schedule constraints. The shortest path problem on the internodal transportation network is concerned with finding a path with minimum distance, time, or cost from an origin to a destination using all possible transportation modalities. The time-schedule constraint requires that the departure time to travel from a transfer station to another node takes place only at one of pre-specified departure times. The scheduled departure times at the transfer station are the times when the passengers are allowed to leave the station to another node using the relative transportation modality. Therefore, the total time of a path in an internodal transportation network subject to time-schedule constraints includes traveling time and transfer waiting time. In this paper, a genetic algorithm (GA) approach is developed to deal with this problem. The effectiveness of the GA approach is evaluated using several test problems.