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Bleomycin에 의해 유발된 Bronchiolitis Obliterans Organizing Pneumonia 1예
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  • Bleomycin에 의해 유발된 Bronchiolitis Obliterans Organizing Pneumonia 1예
저자명
오혜림,강홍모,최천웅,이호종,조용선,유지홍,Oh. Hye-Lim,Kang. Hong-Mo,Choi. Cheon-Woong,Lee. Ho-Jong,Cho. Yong-Seun,Yoo. Jee-Hong
간행물명
결핵 및 호흡기 질환
권/호정보
2001년|50권 4호|pp.504-509 (6 pages)
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대한결핵및호흡기학회
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

There are numerous agents with potential toxic effects on the lung. In particular, cytotoxic drugs constitute the largest and most important group of agents associated with lung toxicity. Bleomycin is commonly used, either alone or in combination with other chemotherapeutic agents, in the treatment of squamous cell carcinoma(head and neck, esophagus, and genitourinary tract), lymphoma, and germ cell tumor. One of the therapeutic advantages of bleomycin is its minimal bone marrow toxicity. However, pulmonary toxicity is one of the most serious adverse side effects. Classically, pulmonary toxicity manifests as a diffuse interstitial process or less commonly as a hypersensitivity reaction. This pulmonary toxicity is generally considered to be dose related and can progress to a fatal fibrosis. It is also possible that bronchiolitis obliterans organizing pneumonia(BOOP) is another manifestation of bleomycin induced toxicity. Bleomycin induced BOOP is less common and has a favorable response to steroid therapy. Here we present a case that demonstrates a BOOP, secondary to a relatively small cumulative dose of bleomycin($225mg/m^2$), may be reversible.