- 딜티아젬서방정을 이용한 In vitro/In vivo 상관성
- ㆍ 저자명
- 최명신,강찬순,최보경,홍정희,김길수,Choi. Myoeng-Sin,Kang. Chan-Soon,Choi. Bo-Kyung,Hong. Chong-Hui,Kim. Kil-Soo
- ㆍ 간행물명
- 藥劑學會誌
- ㆍ 권/호정보
- 2002년|32권 4호|pp.321-325 (5 pages)
- ㆍ 발행정보
- 한국약제학회
- ㆍ 파일정보
- 정기간행물| PDF텍스트
- ㆍ 주제분야
- 기타
IVIVC (In vitro/in vivo correlation) is useful for predicting in vivo results from in vitro data. The aim of this study was to develop IVIVC of sustained release diltiazem. For this purpose, three types of diltiazem tablets with different in vitro dissolution rates were prepared. An in vitro dissolution testing method comprising of paddle apparatus, 50 rpm, water as dissolution medium was developed. Under these condition, we demonstrated that AUCinf could be predicted by evaluating $d_{70%}$ (time dissolved 70%) in vitro since the in vivo AUCinf was correlated with the in vitro $d_{70%}$ (r=-0.9981).