기관회원 [로그인]
소속기관에서 받은 아이디, 비밀번호를 입력해 주세요.
개인회원 [로그인]

비회원 구매시 입력하신 핸드폰번호를 입력해 주세요.
본인 인증 후 구매내역을 확인하실 수 있습니다.

회원가입
서지반출
가미자도환(加味慈桃丸) 구성약물(構成藥物)의 혈관신생(血管新生) 억제효과(抑制效果)에 관한 연구(硏究)
[STEP1]서지반출 형식 선택
파일형식
@
서지도구
SNS
기타
[STEP2]서지반출 정보 선택
  • 제목
  • URL
돌아가기
확인
취소
  • 가미자도환(加味慈桃丸) 구성약물(構成藥物)의 혈관신생(血管新生) 억제효과(抑制效果)에 관한 연구(硏究)
  • Study on the Effects of Jiaweicitaowan (加味慈桃丸) Ingredients on Angiogenic Inhibition
저자명
왕덕중,심범상,안규석,최승훈,Wang. Teh-Chung,Shim. Bum-Sang,Ahn. Kyoo-Seok,Choi. Seong-Hoon
간행물명
大韓韓方腫瘍學會誌
권/호정보
2002년|8권 1호|pp.37-59 (23 pages)
발행정보
대한암한의학회
파일정보
정기간행물|
PDF텍스트
주제분야
기타
이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
서지반출

기타언어초록

Jiaweicitaowan (JWCTW) has been used to inhibit recurrence and metastasis of cancer in clinical practice, Further study has shown its anti-metastatic and anti-angiogenic effects. By applying in vitro and in vivo anti-angiogenic evaluation model, the author assayed the each ingredients of JWCTW. The author performed the following experiments and the results are listed as below: 1. Cell viability assay showed that the viability was almost identical between that of the control and that of the ingredients extract $40{mu}g/ml$ treated, except of hexane fraction of Curcumae Radix $(40{mu}/ml,;2.0\%;of;control)$, ethyl acetate fraction $(40{mu}g/ml,;26.7%)$, butanol fraction $(20{mu}g/ml,;87.2%;;40{mu}g/ml,;12.5%)$ of Cremastrae appendiculatae Tuber, water fraction of Persicae Semen $(40{mu}g/ml,;82.7%)$, ethylacetate fraction of Hippocampus $(40{mu}g/ml,;85.3%)$. 2. The results of gelatin zymogram assay showed that the ingredients of JWCTW decreases the gelatinolytic activity of MMP-9 from ECV304, at the concentration of $10{mu}g/ml$. 3, In in vitro invasion assay, the ingredients of JWCTW effectively inhibited the invasion of cancer cells as compared with the control (+PMA) groups. 4. In capillary-like tube formation assay, the hexane and ethylacetate fractions of Curcumae Radix, Cremastrae appendiculatae Tuber and Persicae Semen showed the dramatic inhibition effects on tube formation of ECV304 at the concentration of $40{mu}g/ml$. 5. In ex vivo rat aortic ring assay, the hexane and ethyl acetate fractions of Curcumae Radix, Cremastrae appendiculatae Tuber and Persicae Semen showed the inhibition effects on angiogenesis of rat aorta at the concentration of $40{mu}g/ml$. According to the above research, the anti-angiogenic effects of the ingredients of JWCTW was proved and it suggested that the more effective prescription for anti angiogensis could be developed.