The pharmacokinetics of intravenous paclitaxel (1 mg/kg) were investigated in rabbits with renal failure induced by folic acid. The area under the plasma concentration-time curve from time zero to time infinity (AUC) of paclitaxel was significantly (p<0.05) greater in rabbits with severe renal failure induced by folic acid $(1030pm382)$ compared to that in rabbits with in moderate renal failure induced by folic acid $(780pm209;ng/ml{cdot}hr)$. The apparent volume of distribution (Vd) $(0.008pm0.002;L/kg)$ and the elimination rate constant $(eta);(0.09pm0.025;hr^{-1})$ of paclitaxel in rabbits with severe renal failure were significantly (p<0.05) smaller and slower respectively than those of control rabbits $(0.016pm0.004;L/kg,;0.12pm0.03;hr^{-1})$, but not significantly different compared with that in rabbits with moderate renal failure $(0.010pm0.003;L/kg,;0.10pm0.026;hr^{-1})$. total body clearance (CL) of paclitaxel in rabbits with severe renal failure $(0.97pm0.183;L/hr/kg)$ was significantly (p<0.05) slower than that in control rabbits $(1.68pm0.440;L/hr/kg)$, but not significantly different compared with that in rabbits with in moderate renal failure $(1.28pm0.311;L/hr/kg)$. The terminal half-life ($t_{1/2}$) of paclitaxel in rabbits with severe renal failure $(7.46pm2.16;hr)$ was significantly (p<0.05) longer than that in control rabbits $(5.75pm1.44;hr)$, but not significantly different compared to that in rabbits with moderate renal failure rabbits $(6.67pm1.76;hr)$. The above data could be at least partly decrease in due to paclitaxel excretion in rabbits with renal failure, since $7-15\%$ of interavenous paclitaxel was excreted via kidney as unchanged forms plus its metablites.