The purpose of this study is to discuss and analyze the effect of blood glucose on treadmill exercise, functional food and their combined treatment protocol on diabetic rats. These group were divided treadmill exercise group(n:12), functional food feeding group(n:12), treadmill exercise with functional food feeding group(n:12) and control group. The following results were obtained from this study. 1. The blood glucose level was showed significantly different in several group, treadmill exercise with functional food feeding group are most significantly on other group. 2. The inhibitory rate of body weight was not significantly different on each group. 3. The amount of feeding was not significantly in several group. 4. The Islets size and Connective tissue proliferation was showed significantly different except control group, treadmill exercise with functional food feeding group are more significantly than other group. These results show that treadmill exercise with functional food feeding and their several protocols can retard the setreptozotocin-induced dibetic rat.