The purpose of this study is to develop an optimal performance design ova concrete median barrier using the design of experiment and crash simulation which is done by Pam-Crash, one of the commercial crash simulation software. A formula of characteristic value was suggested to obtain an optimal performance design considering all of von Mises stress, volume and acceleration at center of gravity of a heavy truck. An optimal design of a concrete median barrier was obtained by the analysis of variance based on design of experiment and crash simulation. A crash simulation with the optimal design was accomplished in order to verify the suitability of the suggested formula and the proper application of the design of experiment. The obtained optimal design was satisfied for a domestic design regulation of a concrete median barrier