The objective of this study was to analyze and make comparison between the physical responses such as oxygen consumption rate, heart rate, and EMG-measurement for lifting tasks. Lifting activities with three different working frequencies(5, 8, 11 lifts/min) and two different weights(10, 20kg) for a lifting range(from floor to 76cm height) were studied. It was found that theme are positive correlations between the oxygen consumption rate and the EMG-measurements on the region of law back. Even though these physical responses were influenced by work weights and work frequency, it was found that the work frequency plays more important role in making muscle fatigue than the work weight. From these finding it is suggested that the work frequency should be considered as a more influencing factor than the work weight as long as the weight belongs to the permissible range based on the viewpoint of the biomechanical criterion for designing a job of manual materials handling tasks.