Six Sigma is one of the most active subjects in quality management. This studs deals with some existing weaknesses that may wise in implementing Six Sigma in real world situations. The main weaknesses discussed here include the lack of understanding of cultural aspects on the nations and industries, the poor linkage between quality, finance and accounting from the bottom line point of view, and the difficult development process of metrics for all improvement results to validate the effect of Six Sigma. Finally, the key success characteristics for a good Six Sigma project are presented.