Screw compressor type chiller is widely used in refrigeration for capacity over 30 RT. To enhance the chiller performance, an economizer which increases the cooling capacity and COP can be adopted. In this study the performance of an economizer is studied by using a simulation program. Simulation results are compared with experiment data to verify the validation of a simulation program. Maximum economizer injection pressure is estimated and the performance of an economizer for various evaporation and condensation temperatures is calculated. From the results, the performance enhancement of an economizer by using R22 and R407C is compared.