Break-in is an intentional treatment to enhance the performance life of machinery parts and to maintain static friction behavior. Most studies on break-in have concerned only about surface conditions such as roughness or film formation. But the exact mechanism of break-in has not been found yet. Friction, scuffing behavior and wear of AISI 1045 were studied in relation to break-in and residual stress. The cylinder-on-disk type tribometer was used with the line-contact geometry. Scuffing tests were carried out using a constant load of 730N. In the break-in procedure the step load was applied from 100N to 200N. In this experiment, it was found that the break-in helps compressive residual stress to be formed well enough to enhance the scuffing life during the scuffing test. Specimens that had high compressive residual stress induced by shot-peening show better wear resistance than those were not shot-peened. Results of scuffing test, break-in procedure and wear amount in relation to residual stress have been discussed.