There has been continuous efforts to manage water resources for the required water quality criterion at river channel in Korea. However, we could obtain the partial improvement only for the point sources such as, waste waters from urban and factory site through the water quality management. Therefore, it is strongly needed that the best management practice throughout the river basin fur water quality management including non-point sources pollutant loads. This problem should be resolved by recognizing the non-point sources pollutant loads from the upstream river basin to the outlet of the basin depends on the landuse and soil type characteristics of the river basin using the computer simulation by a distributed model based on the detailed investigation and application of Geographic Information System (GIS). The purpose of this study is consisted of the three major distributions, which are the investigation of spread non-point sources pollutants throughout the river basin, development of the base maps to represent and interpret the input and outputs of the distributed simulation model, and prediction of non-point sources pollutant loads at the outlet of a up-stream river basin using Agricultural Non-Point Sources Model (AGNPS). For the validation purpose, the Seom-Jin River basin was selected with two flood events in 1998. The results of this application showed that the use of combined a distributed model and an application of GIS was very effective fur the best water resources and quality management practice throughout the river basin