Synthesis and SAR Studies for the Inhibition of TNF-$alpha$ Production. Part 2. 2-[3-(Cyclopenthloxy)4-Methoxyphenyl]-Substituted-1-Isoindolinone Derivatives

Synthesis and SAR Studies for the Inhibition of TNF-$alpha$ Production. Part 2. 2-[3-(Cyclopenthloxy)4-Methoxyphenyl]-Substituted-1-Isoindolinone Derivatives
Synthesis and SAR Studies for the Inhibition of TNF-$alpha$ Production. Part 2. 2-[3-(Cyclopenthloxy)4-Methoxyphenyl]-Substituted-1-Isoindolinone Derivatives

ㆍ 저자명: Park. Joon-Seok,Moon. Seong-Cheol,Baik. Kyung-Up,Cho. Jae-Youl,Yoo. Eun-Sook,Byun. Young-Seok,Park. Myung-Hwan
ㆍ 간행물명: Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
ㆍ 권/호정보: 2002년|25권 2호|pp.137-142 (6 pages)
ㆍ 발행정보: 대한약학회
ㆍ 파일정보: 정기간행물|ENG|
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ㆍ 주제분야: 기타

이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.

서지반출

기타언어초록

This study describes the synthesis and in vitro evaluation of 2-[3- (Cyclopenthloxy) 4-Methoxyphenyl] - Substituted-1-Isoindolinone derivatives substituted on benzene moiety of isoindoline ring for the inhibition of $TNF-{alpha}$ production. From this study, we have found the 6-C position on isoindolinone ring is an optimal derivatization site. Among the compounds synthesized, 6-ammo-2-[3-(cyclopentyloxy)-4-methoxyphenyl]-1-isoindolinone (6) was the most potent in inhibitory activity of $TNF-{alpha}$ production in LPS-stimulated RAW264.7 cells.

키워드

6-ammo-2-[3-(cyclopentyloxy)-4-methoxyphenyl]-1-isoindolinone TNF$alpha$ production inhibitor Structure-activity relationships RAW264 7

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