Previous method of computer simulation to predict the dynamic response of a vehicle has been based on the assumption that vehicle structure is rigid. If the flexibility of the vehicle structure becomes too large to ignore, rigid body assumption will no longer give good estimation of the dynamic characteristics. Therefore, in order to predict more precise vehicle dynamic characteristics, flexible multi-body dynamic analysis of a vehicle is necessary. This paper investigates dynamic characteristics of vehicle systems with flexible frames numerically. Joint reaction forces, vertical accelerations, pitch accelerations are analyzed for the vehicle systems with various flexible frames using multi-body dynamic analysis code and finite element analysis code.