There has been an increasing demand over the years for steels with lower[s] content. For the purpose of improving the efficiency of desulphrization in the powder injection process of ladle, experimental studies were carried out by using cold model to optimize the lance configuration, gas flow rate, immersion depth of lance nozzle, position of lance nozzle relative to the ladle and the effect with slag, etc. As the results of this study, it was made clear that 2-hole nozzle lance (C, E type) placed in an asymmetric position gives the shortest mixing times.