For the light guide plate of the TFT-LCD, there have been increasing demands for higher brightness, thin and light-weight design, and lower power consumption. To meet these demands, a micro-prism-type frontlight that integrates a prismatic sheet and a light-guiding plate has been developed. In this paper, the influences of processing conditions on the brightness were studied lot the injection molding of the light guide plate. Based on the experiment with an actual mold, the design of experiments and the neural network theory were used lot choosing the optimal processing parameters to increase the brightness and the uniformity. The verification experiment also showed that the brightness and the uniformity were increased dramatically with the chosen processing conditions.