In this paper, through the study on locations of structural transducers for active control of the radiated sound from the vibrating plate, the active structural acoustic control (ASAC) system is proposed. And, for the evaluation of the proposed location, the experiment of the active structural acoustic control is implemented using the multi-channel filtered-x LMS algorithm and an additional filter (Acoustic Prediction Filter) to estimate the radiated sound using the acceleration signals of the plate. The structural transducers are piezoceramic actuator (PZT) and accelerometer. PZT is used as an actuator to reduce the vibration and the radiated sound. To maximize the control performance, each PZT actuator is located at the position that has the largest control sensitivity of the plate bending moment in the direction of x and y coordinates and the optimal PZT location is validated experimentally. Also, to find the acoustic prediction filter accurately, two accelerometers are located at the positions that have the largest radiation efficiencies of the plate, and the proposed locations are validated by simulation using the Rayleigh integral. The multi-channel filtered-x LMS algorithm is introduced to control a complex 2-D structural vibration mode. Finding the locations of structural transducers for active structural acoustic control of the radiated sound, the active structural acoustic control (ASAC) system can be presented and validated by experiments using a real time control system.