The objective of this study is to investigate the suitable spatio-temporal analysis method considering the zoning effect of spatial analysis termed the modifiable areal unit problem(MAUP). In former studies of spatio-temporal analysis, there were disagreement between attribute data with spatial data, because of variation of administrative district aggregating attribute data. It is need to consider how the analysis zone effects spatial characteristics and spatio-temporal variation of urban region through land price variation analysis. This study considers MAUP through basic mesh system, which is composed of micro grid. Mesh system can solve disagreement of resolution between spatial data and attribute data.