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서지반출
$eta$-II, III Adrenergic Receptor 유전자 다형성에 따른 20대 한국여성의 식이 섭취량, 비만도 및 체성분의 비교연구
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  • $eta$-II, III Adrenergic Receptor 유전자 다형성에 따른 20대 한국여성의 식이 섭취량, 비만도 및 체성분의 비교연구
저자명
홍정미,김중학,박윤신,최선미,윤유식,안홍석
간행물명
韓國營養學會誌
권/호정보
2002년|35권 8호|pp.870-879 (10 pages)
발행정보
한국영양학회
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
서지반출

기타언어초록

The purpose of this study was to investigate the obesity and state of dietary intake of 216 young Korean females, and the influence of $eta$-II, III Adrenergic receptor (AR) gene polymorphism upon obesity and dietary intake. The average weight, height and BMI of the subjects were 160 cm, 54 kg, and 20.9 kg/$m^2$, respectively. The average triceps skinfold thickness, waist circumference, hip circumference and WHR were 21.7mm, 73.1cm, 93.3cm and 0.78, respectively. The results of body composition measurement using bioimpedance method, average body fluid, body protein, mineral mass and body fat were 29.271, 7.22 kg, 6.79 kg and 19.16 kg, respectively. A dietary survey was conducted using 24-hour recall method. Average calorie intake was 1621 ㎉, which is 81% of Korean RDA. We detected 182 (84.3%) Gln27 (QQ) homozygotes and 34 (15.7%) Gln27Glu (QE) heterozygotes for $eta$-II AR polymorphism. For $eta$-III AR polymorphism, we detected 163 (75.5%) Trp64 (WW) and 53 (24.5%) Trp 64Arg (WR). The results of comparing of obesity by $eta$-II AR gene polymorphism, obesity index and BMI of QE type were slightly higher than those of the QQ type. For $eta$-III AR gene polymorphism, the mean BMI, obesity index, fat mass and percent body fat (%) of the WR type were significantly higher than those of the WW type (p < 0.05). These findings suggest that genetic variability in the human $eta$-III AR is associated with obesity among young Korean females. We also evaluated the effect of the simultaneous presence of the $eta$-II AR and $eta$-III AR polymorphism on obesity. We found that the BMI and obesity index of the mutant type in both $eta$-II AR and $eta$-III AR were significantly higher than those of the type that has only one gene mutation or has no mutation (p < 0.05), indicating a synergistic effect of $eta$-II AR and $eta$-III AR polymorphism on obesity. No association was found between $eta$-II Ad or $eta$-III AR polymorphism and dietary intake.