In VARTM process where a sacrificial medium is used to facilitate the resin flow, the velocity of resin varies drastically between the sacrificial medium and the fiber preform. Although the thickness-to-length ratio of a VARTM product is usually small, a 3-D analysis is prerequisite to analyze the lead-lag flow in the two different media. The problem associated with the full 3-D analysis is the CPU time. A full 3-D numerical mesh comprising large number of nodes requires an impractical CPU time on average computer platforms. In this study, a dual-scale analysis technique was developed. The flow analysis for the entire calculation domain was conducted in 2.5-D, and the 3-D analysis was performed for a small area of special concern. In some numerical examples, the local 3-D analysis could discover an eccentric flow pattern as well as the lead-lag flow that will inevitably be neglected in 2.5-D simulations. The global-local analysis technique practiced in this study can be used to analyze the intricate flow of resin through non-uniform media in affordable CPU times.