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Poly(N-isopropylacrylamide-co-N-vinylpyrrolidone) as a Novel Implant Materials : Preparation and Thermo-Gelling Behavior
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  • Poly(N-isopropylacrylamide-co-N-vinylpyrrolidone) as a Novel Implant Materials : Preparation and Thermo-Gelling Behavior
  • Poly(N-isopropylacrylamide-co-N-vinylpyrrolidone) as a Novel Implant Materials : Preparation and Thermo-Gelling Behavior
저자명
Nam. Irina,Bae. Jin-Woo,Jee. Kyoung-Soo,Lee. Joon-Woo,Park. Ki-Dong
간행물명
Macromolecular research
권/호정보
2002년|10권 2호|pp.115-121 (7 pages)
발행정보
한국고분자학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

Synthesis of polymers with controlled thermosensitive properties was carried out by conventional radical copolymerization of N-isopropylacrylamide (NIPAAm) with N-vinylpyrrolidone (NVP) taken as a hydrophilic comonomer. Lower activity of NVP rather than NIPAAm was revealed by gravimetric and $^1$H NMR analysis. Thermosensitive properties of the copolymers were investigated. It was found that aqueous solutions of the copolymers undergo thermo-induced phase transition and become opaque, precipitate or gel with heating. After formation of the gels their significant contraction was observed at storage. Swelling degree and amount of expelled water were measured in dependence on the copolymer composition, temperature and ionic strength of environment medium and concentration of the solution. It was determined that in collapsed state gels exhibit quite high water content. According to physico-chemical properties of the copolymers observed they could be suitable for biomedical application as an injectable implant material.